chronic granulomatous disease造句

• Mutations in this gene have been associated with chronic granulomatous disease.
• Susanna Raj, 21, has chronic granulomatous disease.
• CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease ( CGD ).
• There are over 410 known possible defects in the PHOX enzyme complex that can lead to chronic granulomatous disease.
• Absence of NADPH oxidase will prevent the formation of reactive oxygen species and will result in chronic granulomatous disease.
• "Granulibacter bethesdensis " was identified in a series of patients with chronic granulomatous disease ( CGD ).
• Nitro blue tetrazolium is used in a diagnostic test, particularly for chronic granulomatous disease and other diseases of phagocyte function.
• In chronic granulomatous disease, gene mutations prevent a type of infection-fighting white blood cell from killing bacteria and fungi.
• Susanna Raj, 21, has chronic granulomatous disease, a genetic disorder that killed her brother and sister when they were children.
• Chronic granulomatous disease affects all people of all races, however, there is limited information on prevalence outside of the United States.
• Interferon-? 1b is approved by the U . S . Food and Drug Administration to treat chronic granulomatous disease and osteopetrosis.
• In 2006, two human patients with X-linked chronic granulomatous disease underwent gene therapy and blood cell precursor stem cell transplantation to their bone marrow.
• Mutations in CYBA or CYBB, encoding p22phox or NOX2, respectively, lead to Chronic granulomatous disease because of the absence of cytb in both cases.
• While the approach offers hope for people with chronic granulomatous disease and other genetic disorders, three of the 10 patients died of the disease or treatment complications.
• The underlying cellular mechanism that causes chronic granulomatous disease was discovered in 1967, and research since that time has further elucidated the molecular mechanisms underlying the disease.
• Mutations in the gene coding for the NADPH oxidase cause an immunodeficiency syndrome called chronic granulomatous disease, characterized by extreme susceptibility to infection, especially catalase-positive organisms.
• The importance of the role of p22phox was evidenced by the discovery of autosomal recessive chronic granulomatous disease caused by mutations in CYBA and leading to the absence of cytb expression in phagocytes.
• (Two other mechanisms are used by phagocytes to kill bacteria : nitric oxide and proteases, but the loss of ROS-mediated killing alone is sufficient to cause chronic granulomatous disease .)
• ""'Penicillium piceum " "'is an anamorph species of the genus of " Penicillium " which can cause in rare cases chronic granulomatous disease.
• As such, Babior was able to explain the etiology of a rare genetic highly fatal immunodeficiency disease, Chronic granulomatous disease, whereby patients are unable to fight off normally non-pathogenic bacteria.